Work

Longitudinal spatial correlation of retinal sensitivity and structural changes in macular telangiectasia type 2

Year: 2026

Type: article

Abstract: PURPOSE: This study aimed to investigate the spatial correlation between retinal structure and function in macular telangiectasia type 2 (MacTel) using Compass fundus-tracked microperimetry. METHODS: Medical records of 54 eyes from 28 patients were retrospectively reviewed. The relationship between retinal sensitivity and structural parameters including retinal thickness, ellipsoid zone (EZ) integrity, and visual acuity was analyzed. Retinal sensitivity was calculated for nine macular sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) grid, and changes over a 2-year follow-up were evaluated. RESULTS: The mean central retinal thickness was 254.3 ± 103.7 μm, and the mean central retinal sensitivity (mRS) was 28.9 ± 5.4 dB. Microscotomas (< 10 dB) were detected in 18.5% of eyes, predominantly in the temporal macula. Although visual acuity and retinal thickness remained stable during follow-up, the central mRS showed a significant decline (29.51 ± 2.02 dB vs. 28.84 ± 1.38 dB, p = 0.038). The spatial distribution of microscotomas corresponded closely to areas of EZ loss, although pointwise mismatch occasionally occurred. CONCLUSION: These findings demonstrate that Compass microperimetry can detect subtle longitudinal functional decline despite a lack of significant change in visual acuity and retinal thickness. These results suggest that microperimetry may serve as a complementary functional biomarker for early disease monitoring in MacTel.

Source: International Journal of Retina and Vitreous

DOI: 10.1186/s40942-026-00873-8

Authors: Seungmo Kim, Yoon Jeon Kim, Young Hee Yoon, Junyeop Lee

Institutions: Veterans Health Service Medical Center, Asan Medical Center, University of Ulsan, Ulsan National Institute of Science and Technology

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,890