Work

Discovery of a Potent, Selective and In Vivo Active Aurora A PROTAC Degrader from a Promiscuous Kinase Inhibitor

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c00183

Authors: Yulin Mao, Meiying Zhang, Hao Tang, Jiaguo Li, Jie Wang, Fengtao Zhou, Jinwei Zhang, Weixue Huang, Xiaomei Ren, Ke Ding, Zhen Wang

Institutions: Jinan University, Chinese Academy of Sciences

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Chinese Academy of Sciences, National Key Research and Development Program of China

Awards: G4258152613, G470197214, G7465765532, G8271943379

OpenAlex ID: W7162803324

FWCI: 1.822

Cites: 34

Cited by: 1

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