Work

Argentatins exert anti-adipogenic and anti-inflammatory effects on 3T3-L1 cells under inflammatory conditions

Year: 2026

Type: article

Abstract: • Argentatins A and B reduce intracellular lipid accumulation without exhibiting cytotoxicity in 3T3-L1 adipocytes. • Argentatin A increases SIRT1 levels and exerts anti-inflammatory effects. • Argentatin B reduces levels of the pro-inflammatory adipokine resistin. • Argentatin B downregulates PPARγ and C/EBPα expression. • Both argentatins exhibit distinct anti-adipogenic and anti-inflammatory activities.

Source: Industrial Crops and Products

DOI: 10.1016/j.indcrop.2026.123521

Authors: Silvia García-Dávila, Miguel Ángel de la Cruz-Morcillo, Cristina Garnés-García, Carmen Cifuentes, Beatriz G. Gálvez, Manuel Carmona, Sílvia Llorens

Institutions: University of Castilla-La Mancha, Instituto Ramón y Cajal de Investigación Sanitaria, Universidad Complutense de Madrid, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,720

Funders: Ministerio de Ciencia, Innovación y Universidades, Universidad de Castilla-La Mancha, Junta de Comunidades de Castilla-La Mancha

OpenAlex ID: W7162845847

FWCI:

Cites: 65

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