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Mindfulness combined with cognitive motor dual task training in Parkinson’s disease with mild cognitive impairment

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Parkinson's disease with mild cognitive impairment (PD-MCI) is a common non-motor manifestation that severely impairs functional independence and quality of life. A single-blind randomized controlled trial was conducted to evaluate whether mindfulness combined with cognitive-motor dual-task training (CMDT) improves multidimensional outcomes in patients with PD-MCI. Fifty three participants were randomly assigned to mindfulness plus CMDT, CMDT alone, or aerobic training for 4 weeks. Compared with the other groups, the combined intervention produced greater improvements in global cognitive function, motor symptoms, depression, sleep quality, quality of life, and postural stability. These findings support a multimodal rehabilitation strategy that simultaneously targets cognitive, motor, and neuropsychiatric pathways in PD-MCI.

Source: iScience

DOI: 10.1016/j.isci.2026.116197

Authors: Rui Wang, Jing-Zhi Zhang, Si-Mao Xu, Jun Chen, Ben-xiang He

Institutions: Guilin Institute of Information Technology, Guangxi Normal University, Sichuan Academy of Traditional Chinese Medicine

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240