Improved Dissolution Performance of Fenoprofen Calcium Using PEG 6000 Solid Dispersions: Preparation by Fusion Method and Physicochemical Characterization
Year: 2026
Type: article
Abstract: Objective: This study aimed to enhance the dissolution performance of poorly water-soluble Fenoprofen calcium by developing solid dispersions using polyethylene glycol 6000 (PEG 6000) via the fusion method. Methods: Solid dispersions were prepared in drug-to-polymer ratios of 1:1, 1:2, and 1:3. The formulations were evaluated for percentage yield, drug content, solubility, and in vitro dissolution. Fourier Transform Infrared Spectroscopy (FTIR) was employed to assess drug-polymer compatibility. Results: The prepared solid dispersions exhibited significantly improved solubility compared to the pure drug. Drug content ranged from 75.0% to 87.5%. Notably, formulation F2 (1:2 ratio) demonstrated the highest dissolution performance, achieving a maximum cumulative drug release of 98.82% within 100 minutes, which was markedly higher than the pure drug. FTIR analysis confirmed the absence of significant drug-polymer interactions, indicating good compatibility and stability of the formulation. Conclusion: Solid dispersion of Fenoprofen calcium using PEG 6000 via the fusion method significantly enhances dissolution behavior. The optimized formulation (F2) shows promising potential for improving oral bioavailability of poorly water-soluble drugs.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7162875076