Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men.
Source: Journal of Epidemiology
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,356
Funders: GlaxoSmithKline, University of Pittsburgh, Kagoshima University, Temple University, Teikyo University School of Medicine, National Cerebral and Cardiovascular Center, Keio University, Kanazawa Medical University, Shimane University, Fukuoka University, Tokyo Medical and Dental University, Ryukoku University, National Institutes of Health, Graduate School of Public Health, University of Pittsburgh, Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute
Awards: G1297380868, International comparison of subclinical atherosclerosis among the Japanese and American men aged 40-49, G1675106894, Association between pericardial fat volume and subclinical atherosclerosis in Japanese men: a 7-year follow-up study, The impacts of ectopic fats in muscle, liver, and abdominal tissues on the metabolism related to glucose and insulin, Gut microbiota and sublinical atherosclerosis in general population, A study on determinants of subclinical atherosclerosis, Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men, Epidemiology of CHD of men aged 40+ in US, Hawaii, Japan, Subclinical atherosclerosis and brain atrophy in general Japanese women : the second phase survey, A population-based epidemiological study on the association between mild cognitive impairment and atherosclerosis, Arrhythmia and subclinical cerebrovascular disease, International collaborative study on subclinical atherosclerosis and its risk factors in three populations in the US and Japan, Explorative Study on new biomarker of atherosclerosis, Subclinical atherosclerosis and brain atrophy in the general Japanese women
OpenAlex ID: W2946257321