Work

Ultrasound-assisted extraction of total flavonoids from Epimedium brevicornu maxim with ionic liquids: Optimization and mechanistic insight

Year: 2026

Type: article

Abstract: • A systematic "theory-to-experiment" paradigm integrating COSMO-RS, RSM, and molecular simulation is established for rational design of ionic liquid extraction systems. • [C₃mim]Cl is identified as the optimal solvent, achieving a total flavonoid yield of 8.15 ± 0.13 mg/g - outperforming conventional ethanol reflux by 9.7% with 77% less extraction time. • Multi-scale mechanistic studies (DFT/MD) reveal that synergistic hydrogen bonding, π-π stacking, and electronic interactions drive the enhanced extraction efficiency. • The recyclability of [C₃mim]Cl was demonstrated, and AGREE assessment confirmed its greener profile (0.66 vs. 0.27), supporting its potential as a sustainable alternative for natural product extraction.

Source: Industrial Crops and Products

DOI: 10.1016/j.indcrop.2026.123583

Authors: Shuang Wang, Yuhan Fang, Lei Diao, Huijie Chen, Zunlai Sheng

Institutions: Northeast Agricultural University, Jilin Agricultural Science and Technology University

Language: English

Topic: Ionic liquids properties and applications

Subfield: Catalysis

Field: Chemical Engineering

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $3,720