Work

Gaussian Mixture Model-Based Focused Refinement for Enhanced Flexible Structure Determination in CryoEM and CryoET

Year: 2026

Type: preprint

Abstract: CryoET. Using a Gaussian mixture model-based focused alignment procedure, we improve resolution of small domains in highly dynamic proteins and reveal intricate conformational changes. The method corrects the per-subunit motion of TRPV1 and captures the rotary dynamics of ATP synthase within mitochondria.

Source: PubMed

DOI: 10.48550/arxiv.2605.30518

Author: Chen, Muyuan

Institutions: SLAC National Accelerator Laboratory, Stanford University

Language: English

Topic: Advanced Electron Microscopy Techniques and Applications

Subfield: Structural Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Energy, National Institutes of Health, SLAC National Accelerator Laboratory

Award: G9000010735

OpenAlex ID: W7162995803

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