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Polymer Materials for Delivery of Short Chain Fatty Acids to the Intestine for Applications in Human Health and Treatment of Disease

Year: 2018

Type: article

Abstract: Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

Source: University of Chicago

DOI: 10.6082/rt8xf-5yq34

Authors: Hubbell, Jeffrey A., Wang, Ruyi, Wilson, D. Scott, Nagler, Cathryn R., Plunkett, Catherine

Institution: University of Chicago

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7163026261

FWCI:

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