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Methods and Compositions Involving Rad51 Inhibitors

Year: 2013

Type: article

Abstract: The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.

Source: University of Chicago

DOI: 10.6082/ec81t-7mt02

Authors: Connell, Philip P., Budke, Brian, Kalin, Jay H., Pawlowski, Michal, Kozikowski, Alan P.

Institution: University of Chicago

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7163034266

FWCI:

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Related to: 10