Work

3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors

Year: 2026

Type: article

Abstract: New HPD analogs potently inhibited purified Mpr in the low nM to sub μM range, but produced modest Gluc reduction due to poor permeability.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00285d

Authors: Muhammad Syafiq Bin Shahari, Jacob P. Mahoney, Ziyue Wang, Anil Pant, Ajit Jagtap, Roshan Katekar, Jiashu Xie, Zhilong Yang, Zhengqiang Wang

Institutions: University of Minnesota, Texas A&M University

Language: English

Topic: Poxvirus research and outbreaks

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Award: Development of novel antivirals against mpox (monkeypox) virus

OpenAlex ID: W7163046361

FWCI: 3.339

Cites: 34

Cited by: 1

Related to: 10