Work

Methods of treating cancer with placenta growth factor peptide linked to immunotherapeutic antibodies

Year: 2018

Type: article

Abstract: The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

Source: University of Chicago

DOI: 10.6082/31sy6-5zs51

Authors: Hubbell, Jeffrey A., Ishihara, Jun, Ishihara, Ako, Fukunaga, Kazuto, Swartz, Melody

Institution: University of Chicago

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7163063473

FWCI:

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Related to: 10