Fibril-blocking peptide, a method for preventing fibril formation
Year: 2000
Type: article
Abstract: A method of minimizing the aggregation tendencies of an amyloid forming protein is provided comprising identifying a portion of the protein that is critical to amyloid formation; and inserting a peptide at the portion. The invention also provides a peptide for insertion in an intact human kappa-IV light chain variable domain, the peptide comprising the following amino acid sequence Phe71-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77 (SEQ ID NO. 1) wherein the subscript numbers are the residue location points in the domain. A method for preventing amyloid formation in human kappa-IV light chain variable domain is also provided, the method comprising inserting the peptide Phe1-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77 (SEQ ID NO. 1) into the domain, wherein the subscript numbers indicate the residue location on the domain.
Source: University of Chicago
DOI: 10.6082/ba4hk-a5637
Institution: Argonne National Laboratory
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7163194026