Year: 2026
Type: preprint
Abstract: Summary Structural comparison of nucleic acids, particularly RNA, is critical for understanding evolutionary and functional relationships beyond sequence similarity, yet efficient tools for large-scale 3D structure search and alignment remain scarce. We extend GTalign to support nucleic acid structures, enabling unified, high-performance alignment across macromolecules. Benchmarking on diverse nucleic acid datasets demonstrates improved alignment accuracy and substantially lower runtimes compared to existing methods. GTalign thus provides a scalable solution for nucleic acid structure comparison and database search. Availability and Implementation: https://github.com/minmarg/gtalign_alpha
Authors: Mindaugas Margelevičius, Shikhar Rana
Institution: Vilnius University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7163218182