Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells
Year: 2026
Type: article
Source: Molecular Therapy
Authors: Lauren E. Sarko, David Givand, Brendan Rattin, Claire Shepley, Anna Tommasi, Allen Attar, Rachel Taylor, Benjamin Kutler, Roshini M. Traynor, Anika Upadhyaya, Mackenzie Mnuk, Cavin Gehrke, Nathan Murren, Tyler K. Ulland, Christian M. Capitini, Theresa Kotanchek, Krishanu Saha
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Wisconsin Alumni Research Foundation, St. Baldrick's Foundation, University of Wisconsin-Madison, Midwest Athletes Against Childhood Cancer, National Institutes of Health, Grainger Institute for Engineering, University of Wisconsin-Madison, National Institute on Aging, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources
Awards: Multi-color Benchtop Flow Cytometer, Biotechnology Training Program, Label-free imaging of CAR T cell metabolism, Graduate Training in Cellular and Molecular Pathogenesis of Human Diseases, UW Comprehensive Cancer Center Support, Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells, ß-hydroxybutyrate inhibition of pathology in Alzheimer's disease
OpenAlex ID: W4415550942