Work

Chemical composition and enzymatic inhibitory activities related to diabetes of Hedychium malayanum rhizome and leaf essential oils essential oils

Year: 2026

Type: article

Abstract: In this study, the composition of essential oils (EOs) from H. malayanum rhizomes and leaves, collected from Bidoup-Núi Bà National Park in Southern Vietnam, and their α-amylase and α-glucodase activity are demonstrated. Gas chromatography-mass spectrometry (GC-MS) analysis identified 34 compounds (99.54%) in rhizome EO and 40 compounds (99.13%) in leaf EO. The major components of rhizome EO included 1,8-cineole (39.33±0.34), β-pinene (23.36±0.13), α-pinene (9.65±0.03), and α-limonene (5.57±0.06), while the leaf EO was rich in β-pinene (57.8±0.25), α-pinene (14.93±0.13), and β-(E)-caryophyllene (9.43±0.17). Both oils exhibited α-amylase inhibitory activity, with IC50 values of 499.10± 6.20 μg/mL (LHM-EO) and 609.04 ± 14.72 μg/mL (RHM-EO), respectively, which were lower than the reference compound, acarbose (IC50 = 271.51±13.51 μg/mL). Unfortunately, both H. malayanum EOs were found to be inactive against α-glucosidase under the tested experimental conditions. To our best knowledge, this is the first report on the composition of rhizome EO and bioactivities of H. malayanum from Vietnam.

Source: Acta chimica slovenica

DOI: 10.17344/acsi.2026.9764