2-((6-metilpiridin-2-il)amino)asetik asid’in in vitro Biyolojik Aktivitesinin Araştırılması
Year: 2025
Type: article
Abstract: Peptoids (N-substituted glycine oligomers) are a class of synthetic heteropolymers that can mimic the structures of peptides. Due to their potent biological activities, their use as drugs in the medical and health sectors is being investigated. This study investigates the in vitro biological activities and drug potential of the peptoid derivative 2-((6-methylpyridin-2-yl)amino)acetic acid. Antioxidant properties were determined by CUPRAC (Cupric Reducing Antioxidant Capacity), DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (Ferric Reducing Antioxidant Power) methods. DNA protection and DNA damage analyses were performed to determine its effects on plasmid DNA. Finally, it’s in vitro inhibitory activity on the enzyme activities of GST (glutathione s-transferase) and hCA I-II (human carbonic anhydrase I-II), important enzymes of various metabolic pathways, was determined. It was found that the highest antioxidant activity of 2-((6-methylpyridin-2-yl)amino) acetic acid was 0.0372±0.0018 µg trolox eq./µL by the CUPRAC method. While the compound did not cause any damage to DNA in the 0.5-1 mg/mL range, it was found to have a DNA protective effect at a concentration of 0.5 mg/mL. Besides, the best inhibitory effect of the compound was shown to be against hCA I isoenzyme.
Source: DergiPark (Istanbul University)
Institutions: Siirt Üniversitesi, Artvin Coruh University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7163698665