Work

1-Deazainosine-impact on RNA structure and role in exploring ribozyme catalysis

Year: 2026

Type: article

Abstract: I supports the hypothesis that an active-site guanine participates directly in phosphodiester-bond cleavage. Together, these results clarify how deazapurines modulate nucleic-acid properties and provide guidance for their use in atomic mutagenesis to interrogate RNA catalysis.

Source: Chemical Science

DOI: 10.1039/d6sc04009h

Authors: Christoph Mitteregger, Raphael Bereiter, Antoine Schramm, Eric Ennifar, Christoph Kreutz, Ronald Micura