Work

Uncompetitive Allosteric Inhibitor of Mitochondrial Creatine Kinase Prevents Binding and Release of Creatine by Stabilization of Loop Closure

Year: 2026

Type: article

Source: Journal of Molecular Biology

DOI: 10.1016/j.jmb.2026.169896

Authors: Merve Demir, Chen-Ting Ma, Nikhil Puvvula, Laura Koepping, Palak Gosalia, Sirkku Pollari, Shaun Alba, Zoe Zong, Ya Li, Lynn Fujimoto, Andrey Bobkov, Taro Hitosugi, Jianhua Zhao, Eduard Sergienko

Institutions: Sanford Burnham Prebys Medical Discovery Institute, National Cancer Institute, Mayo Clinic

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Conrad Prebys Foundation, National Institutes of Health, National Cancer Institute

Awards: G1185958115, Identification of small molecule modulators of mitochondrial creatine kinase 1, G8730722145, Cancer Center Support Grant (CCSG)

OpenAlex ID: W7164000382

FWCI:

Cites: 23

Cited by:

Related to: 10