Work

Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor

Year: 2026

Type: article

Abstract: a PEG spacer and copper-free click chemistry overcomes complement opsonisation. Furthermore, CR2-CR1-conjugated nanoworms reduce complement opsonisation of unmodified nanoparticles.

Source: Chemical Communications

DOI: 10.1039/d6cc00733c

Authors: Sarah Jacques, Hanmant Gaikwad, Jemma Pillatzke, Seyed Moein Moghimi, Dmitri Simberg

Institutions: University of Colorado Anschutz, Trinity College Dublin, Newcastle University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Funders: European Commission, National Institutes of Health, National Institute of Allergy and Infectious Diseases, H2020 Marie Skłodowska-Curie Actions, All of Us Research Program

Awards: The Alternative Complement Pathway and Hemocompatibility of Nanosurfaces, G2382698438, Directing the immune response through designed nanomaterials

OpenAlex ID: W7164032858

FWCI: 1.38

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Cited by: 1

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