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The fungal RIP hypermutator mechanism has deep eukaryotic roots

Year: 2026
Type: article
Abstract: The repeat-induced point mutation (RIP) targets repeated sequences, such as transposable elements, in filamentous fungi. Host-transposable element coevolutionary dynamics have shaped taxonomically restricted eukaryotic defense systems, likely built on conserved ancestral mechanisms. Key questions surrounding homology recognition remain unresolved, and RIP offers a unique opportunity to answer them.
DOI: 10.1016/j.tig.2026.05.008
Institutions: Centre National de la Recherche Scientifique, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Institut de Biologie Intégrative de la Cellule, Institut Pasteur, Université Paris Cité, University of Neuchâtel
Language: English
Open Access status: hybrid
Estimated APC paid: $7,030
OpenAlex ID: W7164154057
FWCI:
Cites: 14
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Related to: 10