Figure 6 from Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring
Year: 2026
Type: other
Abstract: Activation of AMPK signaling enhances the efficacy of KRASG12C inhibition. A and B, Relative viability of H1792 cells treated with sotorasib (Soto; 10 μmol/L) or adagrasib (Adag; 1 μmol/L) alone or in combination with AMPK activators acadesine (AICAR, 0.5 mmol/L) or metformin (Metf, 0.5 mmol/L) for 96 hours. N = 3. C and D, Relative viability of LU99 cells treated with Soto (10 μmol/L) or Adag (1 μmol/L) alone or in combination with AICAR (0.5 mmol/L) or Metf (0.5 mmol/L) for 96 hours. N = 4. Data are presented as the mean ± SD (N = 3) and were analyzed using one-way ANOVA with Tukey post hoc test.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7164306137