Figure 5 from Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring
Year: 2026
Type: other
Abstract: GSTZ1 inhibition enhances AMPK phosphorylation and suppresses survival signaling. A, Immunoblots of H1792 lysates showing levels of phosphorylated and total AKT, ERK, AMPK, mTOR, and GSTZ1 following siGSTZ1, sotorasib (Soto; 1 μmol/L), and combined treatment for 96 hours. B, Quantification of phospho-protein signals relative to actin: p-AKT (S473, N = 5), p-ERK (T202/Y204, N = 3), p-mTOR (S2448, N = 4), and p-AMPK (T172, N = 4). Data represent the mean ± SD and were analyzed by one-way ANOVA with Tukey post hoc test.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7164335665