Work

Chlamydia trachomatis orchestrates multifaceted host cell manipulation for immune evasion

Year: 2026

Type: article

Abstract: Chlamydia trachomatis is an obligate intracellular sexually transmitted human pathogen and a major cause of ocular and urogenital infections worldwide, causing significant reproductive and neonatal complications. Despite eliciting host immune responses, C. trachomatis infections frequently remain asymptomatic, contributing to silent epidemic that often progress to chronic disease. This paradox reflects the remarkable ability of the pathogen to intricately manipulate host cell survival pathways and immune signalling networks. This review synthesizes current knowledge of C. trachomatis pathogenesis and host–pathogen interactions, with a particular emphasis on immune evasion strategies, the implications of which might be effective for therapeutic and preventive approaches. Here we review how Chlamydia trachomatis rewires host cellular pathways to evade immune responses, sustaining a silent epidemic and provide key insights into host–pathogen interactions

Source: Communications Biology

Authors: Deepthi Krishnan Nair Geetha, Paridhi Agarwal, Athulya Thiruvacholayil, Karthika Rajeeve

Institutions: Rajiv Gandhi Centre for Biotechnology, Regional Centre for Biotechnology

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Council of Scientific and Industrial Research, India, University Grants Commission, Science and Engineering Research Board