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Figure S1 from Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring

Year: 2026

Type: other

Abstract: Figure S1 shows the effect of GSTZ1 silencing or knockout on cell viability and sensitivity to KRAS G12C inhibitors across KRAS G12C NSCLC lines in 2D and 3D, and their corresponding immunoblots. It also includes DepMap correlation and survival analysis.

DOI: 10.1158/2767-9764.32647661

Authors: Yi Liao, Xueli Li, Min Liu, Vanessa C. Fernandes, Derek Duckett, Eric B. Haura, Andrii Monastyrskyi, Uwe Rix

Language: English

Topic: Glutathione Transferases and Polymorphisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7164385063

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