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Figure S2 from Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring

Year: 2026

Type: other

Abstract: Figure S2 shows the metabolomics workflow and the effect of GSTZ1 knockdown with or without sotorasib on glutathione, glycolytic, and lipid pathways with enriched pathway annotations. DepMap-based gene expression analysis shows correlation of GSH and GSH metabolism with GSTZ1-targeting effect.

DOI: 10.1158/2767-9764.32647658

Authors: Yi Liao, Xueli Li, Min Liu, Vanessa C. Fernandes, Derek Duckett, Eric B. Haura, Andrii Monastyrskyi, Uwe Rix

Language: English

Topic: Glutathione Transferases and Polymorphisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7164413843

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