Experimenter-free pain assessment in mice using a thermal gradient ring and functional linear models
Year: 2025
Type: preprint
Abstract: Traditional preclinical laboratory animal tests of pain can be suboptimal for many reasons, such as experimenter bias, interference of motor effects, and a lack of emotional or motivational pain process engagement. These shortcomings may also impede the search for novel pain therapies. Recently, thermal preference or gradient tests have gained popularity, and several apparatuses are either commercially available or can be self-made. The thermal gradient ring (TGR) offers a high-resolution thermal preference assessment and removes spatial confounds that may arise in two-chamber or linear designs.
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7164551575