Work

Effects of acidosis and inorganic phosphate on Ca 2+ sensitivity of young and older adult skeletal muscle fibers

Year: 2025

Type: article

Abstract: This study reports the effects of elevated H + and P i on Ca 2+ sensitivity of human skeletal muscle fibers and determines whether the effects of these metabolites are altered by aging in submaximal Ca 2+ . The metabolites markedly depressed Ca 2+ sensitivity in human muscle fibers, but there was no effect of age or sex. These data suggest that Ca 2+ sensitivity is preserved with age in conditions that mimic both quiescent and fatigued muscle.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00445.2025

Authors: Laura E. Teigen, Carlos S. Zepeda, Isabell Dobrzycki, Sandra K. Hunter, Robert H. Fitts, Christopher W. Sundberg

Institutions: Marquette University, University of Wisconsin System, University of Michigan, University of Wisconsin–Madison

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute on Aging