Work

Synthesis, characterization, crystal structures and urease inhibitory activity of new acylhydrazone complex materials

Year: 2026

Type: article

Abstract: In this work, four new oxidovanadium(V) complexes with the general formula [VOLL'] were prepared. L is the dianionic form of 2-hydroxy-5-methyl-N'-(3-methylbenzylidene)benzohydrazide (H2L1) for complexes 1 and 2, and 2-hydroxy-4-methoxy-N'-(3-methylbenzylidene)benzohydrazide (H2L2) for complexes 3 and 4. L' is the deprotonated form of methyl maltol (HLa) for complexes 1 and 3, and ethyl maltol (HLb) for complexes 2 and 4. The structural features of the complexes were assigned using the single crystal X-ray diffraction and other physicochemical techniques. The V atoms in the complexes are in octahedral coordination. Inhibitory activities of the acylhydrazones and complexes were evaluated on Helicobacter pylori urease. All the complexes show effective activity with IC50 values of 15.3-27.2 μmol L-1.

Source: Acta chimica slovenica

DOI: 10.17344/acsi.2026.9815

Authors: Feng-Qian Zou, De-Wen Dong

Institutions: Shenyang Ligong University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry

Language: English

Topic: Vanadium and Halogenation Chemistry

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Shenyang Ligong University

OpenAlex ID: W7164755908

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