Supplementary Figure S14 from Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity
Year: 2026
Type: supplementary-materials
Abstract: Experimental design for the induction of an exhausted phenotype in murine OT-I CD8+ T cells, relative expression of co-receptors, exhaustion markers, and TCF7 in murine CD8+ T cells at different time points of the exhaustion protocol, relative RNA expression of Ccl3, Cxcl13, and Entpd1 genes after one or three stimulations under hypoxia, relative proinflammatory cytokine production and secretion in singly-stimulated or continuously-stimulated T cells under hypoxia, relative expression of PRF1 and GZMB in murine CD8+ T cells after one or three stimulations upon hypoxic exposure, and killing capacity of challenged OT-I cells against B16-OVA melanoma cells.
Authors: Ander de Blas, Massimo Andreatta, Asier Antoñana-Vildosola, Paloma Velasco-Beltrán, Leire Egia-Mendikute, Borja Jiménez-Lasheras, Alexandre Bosch, Adrián Barreira-Manrique, Iker Oyenarte, So Young Lee, Christoph Heuser-Loy, Jeremy G. Baldwin, Roland C. Schelker, Azucena Martín-Santos, Fabio Mastrogiovanni, Mikel Azkargorta, Felix Elortza, James D. Sutherland, Veronica Torrano, Ana M. Aransay, Lorena Pérez-Gutiérrez, Alena Gros, Santiago J. Carmona, Luca Gattinoni, June Ereño-Orbea, Endika Prieto-Fernández, Asis Palazon
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7164805201