Supplementary Figure S6 from Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity
Year: 2026
Type: supplementary-materials
Abstract: Proinflammatory cytokine production in T cells at different stages of the exhaustion protocol under normoxia or hypoxia, secretion of proinflammatory cytokines after one or four stimulations under hypoxia with standard or reduced levels of glucose, and in vitro cytotoxicity assay comparing the killing capacity of hCD19-CAR T cells after one or four stimulations under normoxia or hypoxia against Ramos cell line at different effector to target ratios.
Authors: Ander de Blas, Massimo Andreatta, Asier Antoñana-Vildosola, Paloma Velasco-Beltrán, Leire Egia-Mendikute, Borja Jiménez-Lasheras, Alexandre Bosch, Adrián Barreira-Manrique, Iker Oyenarte, So Young Lee, Christoph Heuser-Loy, Jeremy G. Baldwin, Roland C. Schelker, Azucena Martín-Santos, Fabio Mastrogiovanni, Mikel Azkargorta, Felix Elortza, James D. Sutherland, Veronica Torrano, Ana M. Aransay, Lorena Pérez-Gutiérrez, Alena Gros, Santiago J. Carmona, Luca Gattinoni, June Ereño-Orbea, Endika Prieto-Fernández, Asis Palazon
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7164823463