Yearly attained adherence to Mediterranean diet, estimated trajectories of lipid profile from 60 to 80 years, and onset of clinical dyslipidemias in older adults at high cardiovascular risk
Year: 2026
Type: article
Abstract: PURPOSE: To investigate the association between yearly attained adherence to a Mediterranean diet (MedDiet) and trajectories of triglycerides, high-density lipoprotein cholesterol (HDL-C), and the low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, as well as the risk of clinically relevant dyslipidemias, in adults aged 60-80 at high cardiovascular risk. METHODS: In 4,954 participants (68.1 ± 5.5 years, 62% women, median follow-up: 4 years) from the Prevención con Dieta Mediterránea trial, trajectories of triglycerides, HDL-C, and LDL-C/HDL-C were compared between participants with high or low cumulative adherence to the MedDiet (≥ 10 vs. <10 points) over time. The association between high MedDiet adherence and the risk of five dyslipidemias (triglycerides ≥ 150 or ≥ 200 mg/dL; low HDL-C; LDL-C ≥ 130 or ≥ 160 mg/dL) was examined using multivariable Cox regressions. RESULTS: Compared with low adherence to the MedDiet, high adherence was associated with lower triglycerides (differences in the range: -6 to -12 mg/dL), particularly among individuals using triglyceride-lowering medications (-17 to -41 mg/dL). High adherence was also associated with higher HDL-C (+ 0.8 to + 2.3 mg/dL) and lower LDL-C/HDL-C ratio. High adherence to the MedDiet was associated with a lower risk of all dyslipidemias (range: -21% to -45%). One-point increases in adherence were associated with a 48-91% lower dyslipidemia risk among individuals with low adherence (< 8 points). CONCLUSION: In adults aged 60-80 at high cardiovascular risk, greater long-term adherence to a MedDiet was associated with a better lipid profile and a lower risk of clinically relevant dyslipidemias. TRIAL REGISTRATION NUMBER: ISRCTN35739639 (registration date: Oct 5, 2005).
Source: Lipids in Health and Disease
Authors: Álvaro Hernáez, Camille Lassale, Viviana Sandoval, Emilio Ros, Emilio Ortega, Xavier Pintó, Olga Castañer, Miguel Ángel Martínez‑González, Dolores Corella, Jordi Salas‑Salvadó, Ramón Estruch, Juan Timiraos, José Lapetra, Miquel Fiol, Enrique Gómez‑Gracia, Lluis Serra‑Majem, Karla Alejandra Pérez-Vega, Estefanía Toledo, José V. Sorlí, Nancy Babio, Montserrat Fitó
Institutions: Instituto de Salud Carlos III, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital del Mar Research Institute, Universitat Ramon Llull, Universitat Pompeu Fabra, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Centro de Investigación Biomédica en Red, Barcelona Institute for Global Health, San Sebastián University, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Hospital Clínic de Barcelona, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Harvard University, Navarre Institute of Health Research, Universidad de Navarra, Universitat de València, Institut de Recerca Biomèdica Catalunya Sud, Universitat Rovira i Virgili, Health Research Institute of the Balearic Islands, Hospital Universitario Son Espases, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Universidad de Las Palmas de Gran Canaria, Servicio Canario de la Salud, Hospital Del Mar
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,990
Awards: G8117529026, G8888963831
OpenAlex ID: W7164832500