Work

Estimated Tubular Secretion of Creatinine and Risk of Kidney Failure: The AASK Trial

Year: 2026

Type: article

Abstract: Kidney tubular secretion is an important non-glomerular kidney function and is critical for excretion of toxins and many medications.1,2 Creatinine is freely filtered by the glomerulus and actively secreted by the proximal tubule. Therefore, 24-hour creatinine clearance (CrCl) overestimates glomerular filtration rate (GFR) by 10–20%. In studies that have measured GFR (mGFR) using an isotope such as iohexol or iothalamate, and CrCl, the measured tubular secretion of creatinine (mTScr) can be calculated as the difference between CrCl and mGFR.

Source: Kidney Medicine

DOI: 10.1016/j.xkme.2026.101433

Authors: Pranav S. Garimella, Kevin M. Cummins, Jennifer Gassman, Francis Gabbai, Andrew S. Levey, Joachim H. Ix

Institutions: University of California San Diego, Cleveland Clinic, VA San Diego Healthcare System, Tufts Medical Center

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590