Work

Intervening in aging and related diseases with gene therapy techniques

Year: 2026

Type: review

Abstract: Aging is the primary risk factor for most chronic diseases, and the global rise in aging populations presents an escalating challenge due to functional decline and multimorbidity. Gene therapy provides a versatile framework for modulating aging-regulatory pathways, such as epigenetic regulation, telomere maintenance, and stress-response networks, with the potential to reshape aging trajectories. In this review, we provide an in-depth synthesis of the genetic and epigenetic determinants of aging and highlight advances in gene-based approaches, including genome editing, RNA modulation, and epigenetic reprogramming, all of which hold promise as geroprotective strategies. Furthermore, we discuss mechanistic insights, safety considerations, and translational frameworks, offering a broad, conceptually grounded overview to guide the development of aging gene interventions aimed at improving the healthspan and reducing age-associated dysfunction.

Source: Cell Reports Medicine

DOI: 10.1016/j.xcrm.2026.102870

Authors: Mengmeng Jiang, Jing Qu, Moshi Song, Guang-Hui Liu

Institutions: Chinese Academy of Sciences, Institute of Zoology, Beijing Institute for Stem Cell and Regenerative Medicine, University of Chinese Academy of Sciences

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620