Supplementary Figure S15 from Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity
Year: 2026
Type: supplementary-materials
Abstract: Immunoblots of NRF1-, POMP-, and β1-overexpresing T cells, relative proteasome activity of NRF1-OE and POMP-OE T cells compared to controls, killing capacity of NRF1-OE and POMP-OE hCD19-CAR T cells against hCD19-overexpressing SK-MEL-28 melanoma cells, relative frequency of PD-1+TIM-3+LAG-3+CD39+ T cells in β1-OE or control T cells, and relative expression of TOX in β1-OE T cells or mock controls.
Authors: Ander de Blas, Massimo Andreatta, Asier Antoñana-Vildosola, Paloma Velasco-Beltrán, Leire Egia-Mendikute, Borja Jiménez-Lasheras, Alexandre Bosch, Adrián Barreira-Manrique, Iker Oyenarte, So Young Lee, Christoph Heuser-Loy, Jeremy G. Baldwin, Roland C. Schelker, Azucena Martín-Santos, Fabio Mastrogiovanni, Mikel Azkargorta, Felix Elortza, James D. Sutherland, Veronica Torrano, Ana M. Aransay, Lorena Pérez-Gutiérrez, Alena Gros, Santiago J. Carmona, Luca Gattinoni, June Ereño-Orbea, Endika Prieto-Fernández, Asis Palazon
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7164852520