Self-lubricating anticoagulant surface (SLACS) mimicking heart valve tissue for improving biocompatibility of artificial blood pumps
Year: 2026
Type: article
Abstract: Extracorporeal membrane oxygenation (ECMO) represents the most advanced modalit y of extracorporeal life support. The centrifugal pump head, a key component in direct contact with blood, demands excellent blood compatibility to ensure optimal performance. To address this requirement, a self-lubricating anticoagulant surface (SLACS) was fabricated on a roughened stainless steel substrate through physical adhesion and chemical bonding using a dimethylsiloxane gel (S-PDMS). In the blood slidin g experiment, blood remained on 316 l stainless steel for 6 s but slid off the SLACS in just 0.64 s, demonstrating exceptional resistance to blood adhesion and superior blood compatibility. Applying SLACS to the ECMO centrifugal pump head significantly enhanced its anticoagulant and antibacterial properties, while also exhibiting excellent safety, stability and durability. The feasibility of SLACS as a novel coating was validated through static tests, computational simulations and dynamic experiments, offering a promising solution for improving the safety of ECMO therapy.
Source: Biomedical Materials
Authors: Shiyu Cui, Yaoyao Chen, Jun Zhong, Xuefeng Zhang, Wei Wang, Yuhua Ren, Xiaodan Gou, Yang Cheng, Qing Yang, Feng Chen, Ying He, Lihong Fan
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,325
Award: G8150937621
OpenAlex ID: W7164884473