A fusion-deletion genomic-event underlies poor prognosis in young patients with luminal breast cancer
Year: 2026
Type: article
Study design: Observational Study
Abstract: Breast cancer in young patients, particularly those with the luminal subtype, exhibits more aggressive behavior and poorer clinical outcomes compared with older patients. However, the genomic mechanisms underlying this age-associated aggressiveness remains poorly understood. In this study, we integrated multi-omics data, including gene fusions, mutations, and copy number variations, to investigate age-related molecular heterogeneity in breast cancer. We identified the co-occurrence of the EEF1AKNMT::DNM3 (ED) fusion and KDM6B deletion as a novel prognostic biomarker associated with aggressive tumor biology and reduced survival in luminal breast cancer. Moreover, we discovered a widespread pattern of genomic remodeling in early-onset disease, characterized by an increased fusion burden, distinct mutational profiles, and dysregulated transcriptional programs that collectively contribute to high-risk clinical phenotypes. These findings provide mechanistic insights into the enhanced aggressiveness of breast cancer in young patients and identify potential biomarkers for improved risk stratification.
Source: PLoS ONE
Authors: Le-Wei Zheng, Yi-Ming Liu, Ke-Da Yu, Cui-Cui Liu
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
OpenAlex ID: W7164886294