Work

Dynamic geometry remapping of neural activity within frontal and subcortical areas during decision-making

Year: 2026

Type: preprint

Abstract: Decision-making involves dynamic evaluation of competing options. Recording 16,495 neurons across nine frontal and subcortical areas in macaques revealed brain-wide fluctuations between encoding the attributes of available options. These dynamic representations track deliberation and scale with decision difficulty. Instead of binding attribute information of different options together, our analyses show that these representations are associated with dynamic area- and attribute-specific changes in neural geometry.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.06.11.731612

Authors: Frederic M. Stoll, Neelima Valluru, Peter H. Rudebeck

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Alliance for Research on Schizophrenia and Depression, Philippe Foundation, National Institute of Mental Health

Awards: A new approach to the role of prefrontal-limbic circuits in anxiety disorders, G7464744528, Neural circuit mechanisms of affective probabilistic learning