Work

Oncolytic viruses enhance CAR-T activity for the treatment of pediatric diffuse midline gliomas

Year: 2026

Type: article

Abstract: Diffuse midline glioma (DMG) remains one of the most lethal pediatric brain tumors, with a median survival of less than one year despite aggressive treatment.1 DMGs arise predominantly within midline structures of the central nervous system, most commonly the pons, and tend to occur during defined developmental windows that may confer distinct epigenetic and microenvironmental vulnerabilities.2 Despite substantial advances in the molecular understanding of these tumors, radiotherapy remains the primary established upfront treatment and provides only transient clinical benefit.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201255

Authors: Kyung-Don Kang, Zhuo Zhang, Joshua D. Bernstock, Gregory K. Friedman

Institutions: The University of Texas MD Anderson Cancer Center, Brigham and Women's Hospital, Harvard University

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900