Kolaviron offers significant neuroprotection on potassium dichromate-induced neurobehavioral, biochemical, histopathological, and immunohistochemical changes in rats
Year: 2026
Type: article
Abstract: seeds, has demonstrated antioxidant and anti-inflammatory properties, but its neuroprotective effects against potassium dichromate-induced neurotoxicity remain underexplored. This study investigated the neuroprotective potential of Kolaviron in Wistar rats exposed to potassium dichromate toxicity. Thirty-two adults male Wistar rats were divided into four groups: control, potassium dichromate (2 mg/kg), Kolaviron (100 mg/kg) plus potassium dichromate (2 mg/kg), and Kolaviron (100 mg/kg) alone. Neurobehavioral assessments, oxidative stress biomarkers, antioxidant parameters, histopathological, and immunohistochemical staining of Glial Fibrillary Acidic Protein (GFAP) analyses were conducted. Results indicated that potassium dichromate induced significant neurobehavioral deficits, heightened oxidative stress, neuroinflammation, astrocytosis, and histopathological alterations. However, Kolaviron treatment attenuated oxidative stress, improved cognitive function, and abrogated neuroinflammation, demonstrating its potential as a neuroprotective agent. These findings suggest that Kolaviron could be a promising therapeutic agent for mitigating neurotoxicity and cognitive impairments associated with neurodegenerative diseases.
Source: IBRO Neuroscience Reports
Authors: Temitayo Olabisi Ajibade, Shammah Oluwaseyi Adeyemi, Oluwaseun Olanrewaju Esan, Olanrewaju Samuel Olaifa, Adewumi Victoria Adeogun, Sunday Samuel Adewumi, Glory Oluomachi Uruakpa, Olumayowa Olawumi Igado, Taiwo Olaide Oyagbemi, Ebenezer Oyedele Ajiboye, Fehintoluwa Joy Femi-Olabisi, Temidayo Olutayo Omobowale, Oluwafemi Omoniyi Oguntibeju, Evaristus Nwulia, Momoh Audu Yakubu, Ishmael Festus Jaja, Ademola Adetokunbo Oyagbemi
Institutions: University of Ibadan, Federal College of Animal Health and Production Technology Ibadan, Ajayi Crowther University, Mountain Top University, Cape Peninsula University of Technology, Howard University, Howard University Hospital, Texas Southern University, University of Fort Hare, University of South Africa
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,400
Funder: University of Ibadan
OpenAlex ID: W7164896494