Work

Responsive neurostimulation (RNS) programming

Year: 2026

Type: article

Abstract: Programming of RNS is an iterative process involving a logical progression of patient-specific electrocorticographic biomarker detections that inform stepwise progression of stimulation parameters. In this paper, we discuss the identification and detection of specific pro-ictal, pre-ictal, ictal onset, and seizure body biomarkers as they relate to optimal timing of neurostimulation. General principles underlying different stimulation paradigms are reviewed, and a practical progression of stimulation paradigms is presented with the goals of maximizing the acute seizure-disruptive effects of stimulation as well as the long term neuromodulatory effects, which translate to sustained improvement in seizure frequency and severity.

Source: Neurotherapeutics

DOI: 10.1016/j.neurot.2026.e00944

Authors: Philip M. McCarthy, David E. Burdette

Institutions: Corewell Health, Michigan State University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900