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A Safe Approach to meta ‐Fluorinated Pyridines

Year: 2026

Type: article

Abstract: Since 1947, the Balz-Schiemann reaction has remained the most popular method for the synthesis of meta-fluoropyridines. The method involves dangerous pyridyl diazonium salts and has led to numerous documented explosions. A safe alternative to meta-fluoropyridines has now been developed on the basis of a 1,3-disconnection strategy.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.7155694

Authors: Oleksandra Rushchak, Vadym Sham, Bohdan Dansberg, Andrii Kysil, Tetyana Yegorova, Pavel K. Mykhailiuk

Institutions: Enamine (Ukraine), Institute of Organic Chemistry, Taras Shevchenko National University of Kyiv

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7164925860

FWCI:

Cites: 15

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