Work

High-fat, low-carb diet reduces tumor growth and induces liver metabolism remodeling in a breast cancer mouse model

Year: 2026

Type: article

Abstract: We demonstrate that carbohydrate restriction alone slows breast tumor growth by limiting glucose availability and exposing the metabolic inflexibility of cancer cells. Despite an antitumor effect, carbohydrate restriction also triggers a robust hepatic compensatory response that increases endogenous glucose production. These findings provide important new insights for the design of metabolic interventions in oncology, highlighting the central role of liver-tumor metabolic cross talk and showing that dietary strategies should consider whole body glucose homeostasis.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00878.2025