A case report of primary non-hodgkin lymphoma of the bile duct
Year: 2026
Type: article
Study design: Case Report
Abstract: Primary biliary non-Hodgkin's lymphoma (PBNHL) is an extremely rare biliary malignancy often misdiagnosed as cholangiocarcinoma due to nonspecific imaging. Delayed recognition can result in unnecessary surgery and treatment delays, as chemotherapy is the primary therapy. We report an elderly male presenting with upper abdominal pain, initially suspected of cholangiocarcinoma, but diagnosed with B-cell non-Hodgkin's lymphoma (B-NHL) on histopathology. Due to poor baseline performance and multiple acute complications, he received only two days of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy and subsequently died from sepsis. We report a case of PBNHL, emphasizing its characteristic cholangiographic features and the potential contribution of immunosuppressive conditions, including Epstein-Barr virus (EBV) infection.
Source: Discover Oncology
Authors: Miao-xia Chen, Yong-jian Li, Lei Leng, Xiao-pei Chen, Chuang-jia Zhang, Si-bi Yang, Shu-ya Feng, Wen-feng Deng, Fan Xu
Institution: Guangdong Medical College
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,690
OpenAlex ID: W7164940697