The spatiotemporal distribution of Foxi1-expressing pulmonary ionocytes in the mouse airways
Year: 2026
Type: article
Abstract: This study provides the first spatiotemporal map of Foxi1 + pulmonary ionocytes in mouse airways. These rare cells, which express the majority of CFTR mRNA, emerge postnatally near developing submucosal glands and concentrate in the laryngeal subglottis during adulthood. Their distribution remains unaltered in Cftr ΔF508/ΔF508 mice, suggesting CFTR dysfunction does not disrupt ionocyte patterning.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G5191059288, G7302017591, G848093625
OpenAlex ID: W7164942660