Year: 2026
Type: preprint
Abstract: Gene regulatory networks govern cellular fate decisions through multistable dynamics. The genetic toggle switch is a canonical model of such behaviour; yet, the impact of cell division on its dynamics remains poorly understood. We derive analytical separatrices for a simplified Boolean toggle switch with and without division. We show that division can redirect trajectories with identical initial conditions to opposing stable states, and we define a region of disagreement where fate decisions are predicted incorrectly if division is neglected. Our results imply that division can fundamentally reshape fate boundaries in multistable regulatory networks.
Source: arXiv (Cornell University)
Authors: Austin, Charli, Popovic, Nikola, Grima, Ramon
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Award: G2368803048
OpenAlex ID: W7164949647
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