Work

Multimodal Audiovestibular Assessment After Intratympanic Gentamicin for Vestibular Drop Attacks in Ménière’s Disease: A Case Report and Focused Review

Year: 2026

Type: article

Abstract: Background and Clinical Significance: Vestibular drop attacks are a rare but disabling manifestation of Ménière’s disease. This study aimed to demonstrate the value of multimodal audiovestibular assessment in documenting vestibular deficit after intratympanic gentamicin therapy. Case presentation: A 57-year-old woman with refractory Tumarkin crises underwent serial audiological and vestibular testing before and after intratympanic gentamicin treatment. Post-treatment testing demonstrated right-sided vestibular hypofunction with caloric areflexia, reduced vestibulo-ocular reflex gain, corrective saccades on video head impulse testing, and absent cervical vestibular-evoked myogenic potentials. Hearing thresholds showed transient deterioration with near-baseline recovery during follow-up. Vestibular drop attacks resolved completely. Conclusions: Multimodal audiovestibular assessment provides objective documentation of treatment-induced vestibular hypofunction after intratympanic gentamicin therapy in refractory Ménière’s disease.

Source: Diagnostics

DOI: 10.3390/diagnostics16121860

Authors: Gabriela Cornelia Musat, Codrut Sarafoleanu, Mihai Alexandru Preda, Andreea Alexandra Mihaela Musat, Ionut Tanase

Institution: Carol Davila University of Medicine and Pharmacy

Language: English

Topic: Vestibular and auditory disorders

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137