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FIGURE 1 from Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTNIGF1R

Year: 2026

Type: other

Abstract: Quantification of HNSCC cell numbers following treatment with SSTNIGF1R. A, UM-SCC47 and SCC25 cell lines treated for up to 6 days with a concentration range of either active or inactive mSSTNIGF1R (n = 1; quadruplicate wells/timepoint). B, Growth of five HNSCC cell lines quantified after 4 days treatment with up to 30 μmol/L active mSSTNIGF1R (n = 4; ± SD, Student t test; *, P < 0.01; **, P < 0.001; ***, P < 0.0001). C, Growth of NOK, the, and HaCat nontransformed epithelial cells quantified after 4 days treatment with up to 30 μmol/L active mSSTNIGF1R (n = 3; ± SD, Student t test, not significant). Cell numbers in A,B, and C are quantified using CellTiter-GLO and expressed as relative light units.

DOI: 10.1158/2767-9764.32702555

Authors: Noah A. Stueven, DeannaLee M. Beauvais, Rong Hu, Randall J. Kimple, Alan C. Rapraeger

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7164986489

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