Figure S5 from Synergistic Treatment of Prostate Cancer and Multiple Myeloma using CD46-Targeted Radioimmunotherapy Antibody–Drug Conjugates
Year: 2026
Type: other
Abstract: Figure S5. Hematology and serum-chemistry profiles after single-agent and combination therapy. (A) Violin plots showing white-blood-cell (WBC), red-blood-cell (RBC), and platelet counts on day 15 (acute) and day 120 (chronic) in mice treated with saline (black), [225Ac]Macropa-PEG4-YS5 (4.6 kBq), YS5-MMAE (1.8 mg/kg), or the combination of both agents. (B) Corresponding serum-chemistry parameters; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine, and total bilirubin—measured at the same time points.
Authors: Anil P. Bidkar, Scott Bidlingmaier, Anju Wadhwa, Ellis Mayne, Athira Raveendran, Shubhankar Naik, Cheng Xue, Megha Basak, Kondapa Naidu Bobba, Bonell Patiño-Escobar, Nancy Greenland, Juan Antonio Camara Serrano, Veronica Steri, Jonathan Chou, Arun Wiita, Jiang He, David M. Wilson, Rahul Aggarwal, Henry F. VanBrocklin, Youngho Seo, Bin Liu, Robert R. Flavell
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7164999546