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Oncologic Outcomes After Liver Transplantation for Unresectable Colorectal Liver Metastases: A Systematic Review and Meta‐Analysis of Proportions

Year: 2026
Type: review
Abstract: Liver transplantation has emerged as a therapeutic option for highly selected patients with unresectable colorectal liver metastases (CRLM). This review evaluated oncologic and perioperative outcomes in 92 patients who underwent transplantation. One- and 3-year overall survival (OS) were 96.32% and 73.07%, respectively. Disease-free survival (DFS) was lower, with high rates of recurrence. Major complications occurred in 39.36%, and 90-day mortality was 1.03%. Further randomized studies are needed to better define the role of liver transplantation and optimize patient selection criteria.
DOI: 10.1002/jso.70310
Authors: Bernardo Fontel Pompeu, Lorrany Ramos Aguiar, Giuliana Daneluci Melillo, Laryssa Santana Nakabayashi, Gabriel Leal Barone, Lucas Monteiro Delgado, Claudia Theis, Leonardo de Melo Del Grande, Sérgio Mazzola Poli de Figueiredo, Fernanda Bellotti Formiga, Alexsander Kuroiwa Bressan
Institutions: Universidade Municipal de São Caetano do Sul, Hospital Heliópolis, Universidade Federal de Minas Gerais, University of North Carolina at Chapel Hill, Universidade Federal de São Paulo, University of Calgary
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
OpenAlex ID: W7165000443
FWCI:
Cites: 25
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